Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369838 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A series of arctigenin-4-yl carbamate derivatives were synthesized and evaluated for potency in reducing β-amyloid (Aβ) content in HEK293-APPswe cells. Most of the arctigenin-4-yl aralkyl or aryl carbamate derivatives showed improved potency in reducing Aβ content. Among the synthesized compounds, arctigenin-4-yl (3-chlorophenyl)carbamate (20) exhibited the strongest potency with 78.7% Aβ content reduction at 20 μM. Furthermore, the effect of arctigenin-4-yl (4-chlorophenyl)carbamate (19) and arctigenin-4-yl (3-chlorophenyl)carbamate (20) on lowing Aβ content was better than arctigenin under the concentrations of 1, 10 and 20 μM.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Xingyu Xu, Cong Li, Min Lei, Zhiyuan Zhu, Jianming Yan, Xu Shen, Lihong Hu,