Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369859 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A series of 5,7-dihydroxyflavanone derivatives were efficiently synthesized. Their antimicrobial efficacy on Gram-negative, Gram-positive bacteria and yeast were evaluated. Among these compounds, most of the halogenated derivatives exhibited the best antimicrobial activity against Gram-positive bacteria, the yeast Saccharomyces cerevisiae, and the Gram-negative bacterium Vibrio cholerae. The cytotoxicities of these compounds were low as evaluated on HepG2 cells using a cell viability assay. This study suggests that halogenated flavanones might represent promising pharmacological candidates for further drug development.
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Related Topics
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Organic Chemistry
Authors
Xing Zhang, Omar Khalidi, So Young Kim, Ruitong Wang, Victor Schultz, Brady F. Cress, Richard A. Gross, Mattheos A.G. Koffas, Robert J. Linhardt,