| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369864 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A novel molecule, TatBim-Alexa, consisting of the HIV1 Tat cell-penetrating peptide, the Bim apoptosis-inducing peptide, and Alexa Fluor 546 was synthesized for photoinducion of apoptosis. The Alexa Fluor 546 was used as a photosensitizer and covalently attached at the C-terminus of TatBim peptide by the thiol–maleimide reaction. Photo-dependent cytosolic internalization of TatBim-Alexa and photo-dependent apoptosis using TatBim-Alexa were demonstrated in several kinds of mammalian cells including human cancer cell lines.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazunori Watanabe, Hayato Fujiwara, Mizuki Kitamatsu, Takashi Ohtsuki,