Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369870 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
We have previously reported amidopiperidine derivatives as a novel peptide deformylase (PDF) inhibitor and evaluated its antibacterial activity against Gram-positive bacteria, but poor pharmacokinetic profiles have resulted in low efficacy in in vivo mouse models. In order to overcome these weaknesses, we newly synthesized aminopiperidine derivatives with remarkable antimicrobial properties and oral bioavailability, and also identified their in vivo efficacy against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE) and penicillin-resistant Streptococcus pneumoniae (PRSP).
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hee-Yeol Lee, Kyung-Mi An, Juyoung Jung, Je-Min Koo, Jeong-Geun Kim, Jong-Min Yoon, Myong-Jae Lee, HyeonSoo Jang, Hong-Sub Lee, Soobong Park, Jae-Hoon Kang,