Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369872 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
HCV NS5A inhibitors have demonstrated impressive in vitro potency profiles in HCV replicon assays and robust HCV RNA titer reduction in the clinic making them attractive components for inclusion in an all oral fixed dose combination regimen for the treatment of HCV infection. Herein, we describe research efforts that led to the discovery of a series of fused tricyclic core containing HCV NS5A inhibitors such as 24, 39, 40, 43, and 44 which have pan-genotype activity and are orally bioavailable in the rat.
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Related Topics
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Authors
Wensheng Yu, Craig A. Coburn, De-Yi Yang, Peter T. Meinke, Michael Wong, Stuart B. Rosenblum, Kevin X. Chen, George F. Njoroge, Lei Chen, Michael P. Dwyer, Yueheng Jiang, Anilkumar G. Nair, Oleg Selyutin, Ling Tong, Qingbei Zeng, Bin Zhong, Tao Ji,