| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369923 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators. A methoxy group was optimal for M1 activity and addressed key P-gp issues present in the aforementioned quinolizidinone amide series.
Graphical abstractA series of methoxynaphthalene amides were prepared and evaluated as alternatives to quinolizidinone amide M1 positive allosteric modulators.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Scott D. Kuduk, Christina N. Di Marco, Jonathan R. Saffold, William J. Ray, Lei Ma, Marion Wittmann, Kenneth A. Koeplinger, Charles D. Thompson, George D. Hartman, Mark T. Bilodeau, Douglas C. Beshore,