| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369924 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Many adamantane derivatives have been demonstrated to function as 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors. 3-Amino-N-adamantyl-3-methylbutanamide derivatives were optimized by structure-based drug design. Compound 8j exhibited a good in vitro and ex vivo inhibitory activity against both human and mouse 11β-HSD1.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Younho Lee, Yong June Shin, Soon Kil Ahn,