| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369925 | Bioorganic & Medicinal Chemistry Letters | 2014 | 6 Pages |
Abstract
A series of novel benzamide derivatives were prepared and evaluated using cell-based measurements. Among these compounds, 10f significantly inhibited Hedgehog signaling and showed equivalent or more potency than GDC-0449 in different tests. Furthermore, compound 10f potently inhibited the proliferation of Daoy, a medulloblastoma cell line that is reported to be resistant to GDC-0449, which indicated a promising prospect in the treatment of Hedgehog signaling pathway related cancer in clinical trial.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tian-Ming Wu, Dao-Cai Wang, Pu Xiang, Jian-Nan Zhang, Ya-Xiong Sang, Hong-Jun Lin, Jie Chen, Gang Xie, Hang Song, Ying-Lan Zhao, Yong-Mei Xie,