| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369951 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
High-throughput screening of GSK compound collection led to the discovery of a novel series of thiadiazole amides as potent and S1P3-sparing sphingosine-1-phosphate 1 (S1P1) receptor agonists. Synthesis, structure and activity relationship, selectivity, and some developability properties are described.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Heng Xu, Haibo Zhang, Linbo Luan, Yan Xu, Chengyong Li, Yonghui Wang, Fangbin Han, Ting Yang, Feng Ren, Jia-Ning Xiang, John D. Elliott, Yonggang Zhao, Taylor B. Guo, Hongtao Lu, Wei Zhang, David Hirst, Matthew Lindon, Xichen Lin,