| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369953 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A ligand-based approach to identify potential starting points for a dual MCH-1R antagonist/DPPIV inhibitor medicinal chemistry program was undertaken. Potential ligand pairs were identified by analysis of MCH-1R and DPPIV in vitro data. A highly targeted synthetic effort lead to the discovery of pyridone 11, a dual MCH-1R antagonist/DPPIV inhibitor with selectivity over DPP8 and DPP9.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
William T. Gattrell, Colin P. Sambrook Smith, Alun J. Smith,