| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369959 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A novel class of DGAT1 inhibitors containing a thiadiazole core has been discovered. Chemical optimization lead to inhibitors of human DGAT1 with an appropriate ADME profile and that show in vivo activity in target tissues.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Patrick Mougenot, Claudie Namane, Eykmar Fett, Florence Camy, Rommel Dadji-Faïhun, Gwladys Langot, Catherine Monseau, Bénédicte Onofri, François Pacquet, Cécile Pascal, Olivier Crespin, Majdi Ben-Hassine, Jean-Luc Ragot, Thao Van-Pham,