| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369960 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.
Graphical abstractNew dimeric compounds of alternariol class, verrulactones A (1) and B (2), were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC50 of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus including MRSA with MICs of 8 and 16 μg/mL, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
