| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369973 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Abstract
Purinergic receptor P2X3 has been linked to analgesia in a number of pre-clinical models of pain, and is expressed in the human pain perception pathway. Only few P2X3-selective antagonists have been reported to date. This Letter describes the SAR and in vivo analgesic profile of a novel scaffold of selective P2X3 antagonists.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Louis-David Cantin, Malken Bayrakdarian, Christophe Buon, Eric Grazzini, Yun-Jin Hu, Jean Labrecque, Carmen Leung, Xuehong Luo, Giovanni Martino, Michel Paré, Kemal Payza, Nirvana Popovic, Denis Projean, V. Santhakumar, Christopher Walpole, Xiao Hong Yu,