Article ID Journal Published Year Pages File Type
1369979 Bioorganic & Medicinal Chemistry Letters 2012 4 Pages PDF
Abstract
Optimization of oxazole-based PDE4 inhibitors has led to the discovery of a series of quinolyl oxazoles, with 4-benzylcarboxamide and 5-α-aminoethyl groups which exhibit picomolar potency against PDE4. Selectivity profiles and in vivo biological activity are also reported.
Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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