| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369979 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Optimization of oxazole-based PDE4 inhibitors has led to the discovery of a series of quinolyl oxazoles, with 4-benzylcarboxamide and 5-α-aminoethyl groups which exhibit picomolar potency against PDE4. Selectivity profiles and in vivo biological activity are also reported.
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Authors
Rongze Kuang, Ho-Jane Shue, Li Xiao, David J. Blythin, Neng-Yang Shih, Xiao Chen, Danlin Gu, John Schwerdt, Ling Lin, Pauline C. Ting, Jianhua Cao, Robert Aslanian, John J. Piwinski, Daniel Prelusky, Ping Wu, Ji Zhang, Xiang Zhang, Chander S. Celly,