| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369985 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The ceramide-sphingosine-1-phosphate rheostat is a promising therapeutic target. Here, the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide is shown to block proliferation and enhance the efficacy of the clinical chemotherapeutics, etoposide and doxorubicin. These results demonstrate the therapeutic potential of this compound in treating both endocrine resistant and chemoresistant breast cancer.
Keywords
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
James W. Antoon, Barbara S. Beckman,