| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369986 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
The discovery of GS-9451 is reported. Modification of the P3 cap and P2 quinoline with a series of solubilizing groups led to the identification of potent HCV NS3 protease inhibitors with greatly improved pharmacokinetic properties in rats, dogs and monkeys.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
X. Christopher Sheng, Todd Appleby, Thomas Butler, Ruby Cai, Xiaowu Chen, Aesop Cho, Michael O. Clarke, Jeromy Cottell, William E. Delaney IV, Edward Doerffler, John Link, Mingzhe Ji, Rowchanak Pakdaman, Hyung-Jung Pyun, Qiaoyin Wu, Jie Xu,