Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369997 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
In the present study, three series of dimethylamino curcuminoids viz. 4-phenylaminomethyl curcumin (3a–d), arylidene curcumin (3e) and pyrazole curcumin (3f–i) derivatives have been synthesized and studied for their in vitro anti-inflammatory, antioxidant and antibacterial activities. Synthesized dimethylamino curcuminoid derivatives namely 3d, 3e, 3h and 3i have shown potent anti-inflammatory properties than parent curcumin. Molecular docking interactions of dimethylamino curcuminoids derivatives against cyclooxygenase enzymes (COX-1 and COX-2) were studied.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Govindharasu Banuppriya, Rajendran Sribalan, Vediappen Padmini, Vellasamy Shanmugaiah,