Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370000 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
The novel analysis method consisting of size-exclusion chromatography (SEC) and HRMS analysis was firstly applied in the discovery of potential inhibitors towards cancer drug targets. With vascular endothelial growth factor receptor (VEGFR-2) as a target, dynamic combinatorial libraries (DCLs) were prepared by reacting aldehydes with amines. Four sensitive binders targeted VEGFR-2 were directly isolated from the library. Antitumor activity test in vitro and inhibition experiments toward angiogenesis were also carried out.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zhao Yang, Zheng Fang, Wei He, Zhixiang Wang, Haifeng Gan, Qitao Tian, Kai Guo,