| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370006 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dnyaneshwar D. Subhedar, Mubarak H. Shaikh, Manisha A. Arkile, Amar Yeware, Dhiman Sarkar, Bapurao B. Shingate,