Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370035 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
In this study, a series of bis(4-hydroxy)benzophenone oxime ether derivatives such as 12c, 12e and 12h were identified as novel estrogen receptor (ER) agonists that have additional and complementary anti-proliferative activities via ER-independent mechanism in cancer cells. These compounds are expected to overcome the therapeutic limitation of existing ER agonists such as estradiol and tamoxifen, which have been known to induce the proliferation of cancer cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Taelim Kim, Hye-In Kim, Ji-Young An, Jun Lee, Na-Rae Lee, Jinyuk Heo, Ji-Eun Kim, Jihyun Yu, Yong Sup Lee, Kyung-Soo Inn, Nam-Jung Kim,