Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370037 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
D1 protease is a C-terminal processing protease that has been predicted to be an ideal herbicidal target. Three novel series of benzothiazole derivatives were synthesized and evaluated for their herbicidal activities against Brassica napus (rape) and Echinochloa crusgalli (barnyard grass). The preliminary bioassay indicated that most of the synthesized compounds possess promising D1 protease inhibitory activities and considerable herbicidal activities. Molecular docking was performed to position representative compounds into the active site of D1 protease to determine a probable binding model.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Tonghui Huang, Jie Sun, Lin An, Lixian Zhang, Cuiping Han,