| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370052 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A series of novel carbazole-containing sulfonamides and sulfamides were synthesized. A structure–activity relationship study of these compounds led to the identification of potent cryptochrome modulators. Based on the results of efficacy studies in diet-induced obese (DIO) mice, and the desired pharmacokinetic parameters, compound 41 was selected for further profiling.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul S. Humphries, Ross Bersot, John Kincaid, Eric Mabery, Kerryn McCluskie, Timothy Park, Travis Renner, Erin Riegler, Tod Steinfeld, Eric D. Turtle, Zhi-Liang Wei, Erik Willis,