Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370060 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A new method was developed for one-pot green synthesis 1,3,5-triarylpentane-1,5-dione, triarylmethane, and flavonoid derivatives from the reaction between 2,4-dihydroxybenzaldehyde and hydroxyacetophenones via Aldol, Michael, and Friedel–Crafts additions using boric acid as catalyst in polyethylene glycol 400. The synthetic compounds demonstrated significant tyrosinase inhibitory activities much stronger than that of kojic acid. More important, 1,3,5-triarylpentane-1,5-dione and triarylmethane derivatives were found to be a new class of tyrosinase inhibitors.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zong-Ping Zheng, Yi-Nan Zhang, Shuang Zhang, Jie Chen,