| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370062 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
A range of di- and triaryl benzamides were synthesised to investigate the effect of the presence and nature of a polar sidechain, bonding and substitution patterns and functionalisation of benzylic substituents. These compounds were tested for their antiproliferative activity as well as their DNA binding activity. The most active compounds in all assays were unsymmetrical triaryl benzamides with a bulky or alkylating benzylic substituent and a polar amino sidechain.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gul Shahzada Khan, Lisa I. Pilkington, David Barker,