| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370066 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
The HIV-1 CA protein is an attractive therapeutic target for the development of new antivirals. An inter-protomer pocket within the hexamer configuration of the CA, which is a binding site for key host dependency factors, is an especially appealing region for small molecule targeting. Using a field-based pharmacophore derived from an inhibitor known to interact with this region, coupled to biochemical and biological assessment, we have identified a new compound that inhibits HIV-1 infection and that targets the assembled CA hexamer.
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Related Topics
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Organic Chemistry
Authors
Jimmy P. Xu, Jeffrey D. Branson, Rae Lawrence, Simon Cocklin,