| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370092 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Exploring copper(I)- and ruthenium(II)-catalyzed azide–alkyne cycloadditions and a Sonogashira protocol, novel cytostatic ferrocene-cinchona hybrids were synthetized displaying significant in vitro activity on HepG-2 and HT-29 cells. Preliminary SAR studies disclosed that compounds incorporating linkers with 1,2,3-triazole and chalchone residues can be considered as promising lead structures. According to the best of our knowledge this is the first letter on the incorporation of ferrocene nucleus in the reputed cinchona family via triazole and chalcone linkers with established pharmaceutical profile.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
László Kocsis, Ildikó Szabó, Szilvia Bősze, Tamás Jernei, Ferenc Hudecz, Antal Csámpai,