| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370130 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
The structure–activity relationships of a novel series of biaryl dihydroorotate dehydrogenase (DHODH) inhibitors related to teriflunomide are disclosed. These biaryl derivatives were the result of structure-based design and proved to be potent DHODH inhibitors which in addition showed good antiproliferative activities on peripheral blood mononuclear cells and good efficacies in vivo in the rat adjuvant-induced-arthritis model.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Montse Erra, Imma Moreno, Jordi Sanahuja, Miriam Andrés, Raquel F. Reinoso, Estrella Lozoya, Pilar Pizcueta, Núria Godessart, Julio Cesar Castro-Palomino,