| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370158 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
We report the first synthesis of the C-terminally spermine-conjugated stapled peptide-based inhibitors of the p53-Mdm2 interaction. Subsequent biological, biophysical and cellular uptake assays with the spermine-conjugated stapled peptides revealed that spermine conjugation minimally affects biological activity while significantly increases peptide helicity and cellular uptake without apparent cytotoxicity.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Avinash Muppidi, Xiaolong Li, Jiandong Chen, Qing Lin,