| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370161 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methylamino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.
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Related Topics
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Authors
Richard R. Copp, Daniel D. Peebles, William E. Fahl,