| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370172 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A newly series of 4-(phenylurenyl)chalcone (4a–j) and 4′-(phenylurenyl/thiourenyl)chalcone (9a–l) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. Tyrosinase has been purified from banana on an affinity gel comprised of Sepharose 4B-l-tyrosine-p-aminobenzoic acid. The result showed that 4a–j inhibited the PPO enzyme activity. Conversely, 9a–h and 9i–l showed activator effect on tyrosinase enzyme activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Fatih Sonmez, Sedat Sevmezler, Alparslan Atahan, Mustafa Ceylan, Dudu Demir, Nahit Gencer, Oktay Arslan, Mustafa Kucukislamoglu,