Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370173 | Bioorganic & Medicinal Chemistry Letters | 2011 | 6 Pages |
Abstract
As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoisomerases II and IV. We have investigated various subunits in this series and report advanced studies on compound 7 which demonstrates good PK and in vivo efficacy properties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Timothy J. Miles, Christopher Barfoot, Gerald Brooks, Pamela Brown, Dongzhao Chen, Steven Dabbs, David T. Davies, David L. Downie, Susanne Eyrisch, Ilaria Giordano, Michael N. Gwynn, Alan Hennessy, Jennifer Hoover, Jianzhong Huang, Graham Jones,