| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370174 | Bioorganic & Medicinal Chemistry Letters | 2011 | 7 Pages |
Abstract
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad spectrum antibacterial activity and demonstrates oral efficacy in a rat lung infection model.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Timothy J. Miles, Jeffrey M. Axten, Christopher Barfoot, Gerald Brooks, Pamela Brown, Dongzhao Chen, Steven Dabbs, David T. Davies, David L. Downie, Susanne Eyrisch, Timothy Gallagher, Ilaria Giordano, Michael N. Gwynn, Alan Hennessy, Jennifer Hoover,