Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370177 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
An efficient and straightforward synthesis of a novel m-phenylene derivative has been developed. The optically pure dibromo compound was selected as a starting material. Through a protocol involving the Prins reaction and two steps of the Horner–Wadsworth–Emmons reaction, the basic skeleton was constructed with appropriate alpha and omega side chains. The compound proved to be a highly selective EP4 agonist and a possible drug candidate for maturation of the uterine cervix.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ryoji Hayashi, Yutaka Hosono, Koji Nakatsuji, Yoichiro Tanaka, Takeshi Mori, Takami Kanno, Kei Makita, Mitsuhiro Moriwaki, Tomofumi Ohyama, Yasuo Ochi, Chifumi Inada, Masafumi Isogaya,