| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370229 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A Phenotypic Drug Discovery strategy was applied to study a set of pyrimidine analogs prepared by means of intramolecular oxidation–reduction reactions of N-substituted-N-(2,6-disubstituted-5-nitro-4-pyrimidinyl)aminoacetic acid methyl esters in basic media. The combined and rational use of specific assays allowed in short time reducing from all possible cellular targets to those involved in metaphase to anaphase transition.
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Related Topics
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Organic Chemistry
Authors
Carla Ríos-Luci, Raquel Domínguez-Kelly, Leticia G. León, Elena Díaz-Rodríguez, Raimundo Freire, Atanasio Pandiella, Inga Cikotiene, José M. Padrón,