| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370241 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
The synthesis of a series of benzocoumarin keto-enamine schiff bases is reported. The novel compounds were evaluated for their antihyperlipidemic activity in the hyperlipidemic hamster model. The compound 11 at a dose of 10 mg/kg body weight significantly lowered the plasma triglyceride levels (TG) by 70%, total cholesterol (TC) by 47%, accompanied by an increase in HDL-C/TC ratio by 80% in hyperlipidemic hamsters to a greater degree than the reference drugs atorvastatin and lovastatin.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis and antidyslipidemic activity of novel benzocoumarins is reported. ► Compound 11 showed better activity than the reference drugs in HFD fed hamsters. ► Dose response studies revealed 25 mg/kg as most optimum dose.
