| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370253 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
A novel series of potent inhibitors of glucosylceramide synthase are described. The optimization of biochemical and cellular potency as well as ADME properties led to compound 23c. Broad tissue distribution was obtained following oral administration to mice. Thus 23c could be another useful tool compound for studying the effects of GCS inhibition in vitro and in vivo.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Elena Koltun, Steven Richards, Vicky Chan, Jason Nachtigall, Hongwang Du, Kevin Noson, Adam Galan, Naing Aay, Art Hanel, Amanda Harrison, Jeff Zhang, Kwang-Ai Won, Danny Tam, Fawn Qian, Tao Wang, Patricia Finn, Kathleen Ogilvie, Jon Rosen, Raju Mohan,