| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370256 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Abstract
Based on the anti-hepatitis C activity of 2′-C-methyl-adenosine and 2′-C-methyl-guanosine, a series of new modified purine 2′-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2′-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.
Graphical abstractA series of new purine modified 2′-C-methyl nucleosides was prepared and evaluated as potential anti-hepatitis C virus agents.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hong-wang Zhang, Longhu Zhou, Steven J. Coats, Tamara R. McBrayer, Phillip M. Tharnish, Lavanya Bondada, Mervi Detorio, Sarah A. Amichai, Melissa D. Johns, Tony Whitaker, Raymond F. Schinazi,