| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370274 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
New N-acylhomoserine lactone (AHL) analogues in which the amide function is replaced by a reverse-amide one have been studied as AHL QS modulators. The series of compounds consists of α-(N-alkyl-carboxamide)-γ-butyrolactones, α-(N-alkyl-sulfonamide)-γ-butyrolactones, and 2-(N-alkyl-carboxamide)-cyclopentanones and cyclopentanols. Most active compounds exhibited antagonist activities against LuxR reaching the 30 μM range.
Graphical abstractNew N-acylhomoserine lactones (AHLs) analogues in which the amide function is replaced by a reverse-amide or a reverse-sulfonamide one have been studied as AHL-dependent QS modulators.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mohamed Boukraa, Mohamad Sabbah, Laurent Soulère, Mohamed L. El Efrit, Yves Queneau, Alain Doutheau,