| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370281 | Bioorganic & Medicinal Chemistry Letters | 2011 | 7 Pages |
Abstract
The synthesis, evaluation, and structure–activity relationships of a set of related constrained diaminopropane inhibitors of BACE-1 are described. The full in vivo profile of an optimized inhibitor in both normal and P-gp deficient mice is compared with data generated in normal rats.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lorin A. Thompson, Jianliang Shi, Carl P. Decicco, Andrew J. Tebben, Richard E. Olson, Kenneth M. Boy, Jason M. Guernon, Andrew C. Good, Ann Liauw, Changsheng Zheng, Robert A. Copeland, Andrew P. Combs, George L. Trainor, Daniel M. Camac,