| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370326 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
The known DNMT inhibitor SGI-1027 4 has been synthesized using as key steps Pd-catalyzed Ar–N bond formation reactions performed in a sequential or convergent manner. In the former approach, a by-product, which corresponds to the incorporation of two units of 4-chloroquinoline, was also isolated. The biological effects of compound 4 in the U937 human leukemia cell line are also described.
Graphical abstractThe quinoline-based compound SGI-1027 has been synthesized using Pd-catalyzed Ar–N bond construction on a sequential or a convergent manner. Its activity as DNMT1 inhibitor and the biological effects in the U937 human leukemia are described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Patricia García-Domínguez, Carmela Dell’Aversana, Rosana Alvarez, Lucia Altucci, Ángel R. de Lera,