Article ID Journal Published Year Pages File Type
1370332 Bioorganic & Medicinal Chemistry Letters 2013 5 Pages PDF
Abstract

We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)–selective inhibitor (BMS309403) complex and FABP3–elaidic acid complex. Some of the synthesized compounds exhibited dual FABP3/4 ligand activity, and some exhibited selectivity for FABP3.

Graphical abstractIn order to create FABP3 ligands, a new series of pyrazole-based carboxylic acids were designed and synthesized based on the X-ray crystallographic result of the structure of BMS309403, other FABP subtype of FABP4–selective inhibitor–FABP4 complex as a template.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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