Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370332 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)–selective inhibitor (BMS309403) complex and FABP3–elaidic acid complex. Some of the synthesized compounds exhibited dual FABP3/4 ligand activity, and some exhibited selectivity for FABP3.
Graphical abstractIn order to create FABP3 ligands, a new series of pyrazole-based carboxylic acids were designed and synthesized based on the X-ray crystallographic result of the structure of BMS309403, other FABP subtype of FABP4–selective inhibitor–FABP4 complex as a template.Figure optionsDownload full-size imageDownload as PowerPoint slide