| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370351 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
TMPRSS4 is a novel type II transmembrane serine protease that has been implicated in the invasion and metastasis of colon cancer cells. In this study, a novel series of 2-hydroxydiarylamide derivatives were synthesized and evaluated for inhibiting TMPRSS4 serine protease activity and suppressing cancer cell invasion. These derivatives demonstrated good inhibitory activity against TMPRSS4 serine protease, which correlated with the promising anti-invasive activity of colon cancer cells overexpressing TMPRSS4.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sunghyun Kang, Hye-Jin Min, Min-Seo Kang, Myung-Geun Jung, Semi Kim,