| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370364 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Eighteen new hydrazino-1,3-thiazole derivatives were evaluated against 8 strains of multi-resistant Candida spp. Introduction of an indolyl moiety linked to the hydrazone function enhanced the in vitro anti-Candida activity, with an activity spectrum towards Candida albicans strains. Introduction of a (S)-2-aminoethyl chain on the thiazole nucleus largely enhanced the in vitro antifungal activity, with a selectivity oriented towards non-C. albicans species.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Ludovic T. Maillard, Sébastien Bertout, Ophélie Quinonéro, Gülşen Akalin, Gülhan Turan-Zitouni, Pierre Fulcrand, Fatih Demirci, Jean Martinez, Nicolas Masurier,