| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370370 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A high-throughput screen (HTS) was conducted against stably propagated cancer stem cell (CSC)-enriched populations using a library of 300,718 compounds from the National Institutes of Health (NIH) Molecular Libraries Small Molecule Repository (MLSMR). A cinnamide analog displayed greater than 20-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_eGFP). Herein, we report structure–activity relationships of this class of cinnamides for selective lethality towards CSC-enriched populations.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew R. Germain, Leigh C. Carmody, Partha P. Nag, Barbara Morgan, Lynn VerPlank, Cristina Fernandez, Etienne Donckele, Yuxiong Feng, Jose R. Perez, Sivaraman Dandapani, Michelle Palmer, Eric S. Lander, Piyush B. Gupta, Stuart L. Schreiber,