| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370372 | Bioorganic & Medicinal Chemistry Letters | 2013 | 7 Pages |
Abstract
A series of indazolo[4,3-gh]isoquinolinones derivatives have been synthesized to decrease cardiotoxic side effects in comparison to Mitoxantrone. The antiproliferative effects of different side chains were investigated and tested on at least four different cell lines of cervix, ovarian, CNS, NSCLC (non-small-cell lung cancer) and colon carcinoma. In addition to antiproliferative activities, influence on cell cycle and intercalation behavior have been tested.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives](/preview/png/1370372.png "First Page Preview: Synthesis and biological evaluation of new cytotoxic indazolo[4,3-gh]isoquinolinone derivatives")
Authors
Manochehr Shahabi, Eva Schirmer, Karem Shanab, Theerachart Leepasert, Jana Ruzicka, Wolfgang Holzer, Helmut Spreitzer, Babette Aicher, Peter Schmidt, Lars Blumenstein, Gilbert Müller, Eckhard Günther,