Article ID Journal Published Year Pages File Type
1370377 Bioorganic & Medicinal Chemistry Letters 2013 4 Pages PDF
Abstract

Malaria is a disease that has a major impact in many developing nations, especially on the African continent. There is a need to develop new therapeutics and prophylactic treatments against it. A trisubstituted pyrrole was recently found to inhibit infection of mammalian hepatocytes by Plasmodium sporozoites, but the target of this agent is not known. In this study trisubstituted pyrrole derivatives with different substituents on a piperidinyl nitrogen were prepared. We determined if modifications of the piperidinyl nitrogen would accommodate a drug–biotin linking strategy for affinity purification of the trisubstituted pyrrole’s target protein(s).

Graphical abstractTrisubstituted pyrrole.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
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