| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370379 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
Conformationally constrained spirocycles (17–23) and (31–36) were synthesised. In vitro data revealed that these compounds are CCR1 antagonists with sub-nanomolar potency. In a functional assay 22, 23 and 36 inhibited CCR1 mediated chemotaxis with an IC50 value of 2, 2.6 and 68 nM, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nafizal Hossain, Svetlana Ivanova, Jonas Bergare, Tomas Eriksson,