| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370394 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
A library of chemokine antagonists has been synthesized using a combination of solid and solution-phase chemistry. Structures of known chemokine antagonists were used to produce a pharmacophore which served to guide monomer selection. Several combinations of monomers have resulted in providing novel chemokine antagonists which in some cases display dual chemokine receptor antagonism.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gurdip Bhalay, Birgit Albrecht, Mohammed Akhlaq, Urs Baettig, David Beer, Zarin Brown, Steven Charlton, Andrew Dunstan, Michelle Bradley, Peter Gedeck, Angela Glen, Trevor Howe, Thomas Keller, Juliet Leighton-Davies, Alice Li, Clive McCarthy,