Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1370404 | Bioorganic & Medicinal Chemistry Letters | 2011 | 4 Pages |
Abstract
Design, synthesis and insight into the structure–activity relationship (SAR) of 1,3-disubstituted indazoles as novel HIF-1 inhibitors are described. In particular, the substituted furan moiety on indazole skeleton as well as its substitution pattern turns out crucial for the high HIF-1 inhibition.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongchan An, Nam-Jung Kim, Jong-Wha Jung, Hannah Jang, Jong-Wan Park, Young-Ger Suh,