| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1370406 | Bioorganic & Medicinal Chemistry Letters | 2011 | 5 Pages |
Lysine-nitrile derivatives having a trisubstituted benzene, which belongs to a new chemical class, were prepared and tested for inhibitory activities against plasmin and the highly homologous plasma kallikrein and urokinase. The use of the novel chemotype in the development of plasmin inhibitors has been demonstrated by derivatives of compound 9.
Graphical abstractLysine-nitrile derivatives having a trisubstituted benzene, which belongs to a new chemical class, were prepared and tested for inhibitory activities against plasmin and the highly homologous plasma kallikrein and urokinase. The use of the novel chemotype in the development of plasmin inhibitors has been demonstrated by derivatives of compound 9.Figure optionsDownload full-size imageDownload as PowerPoint slide
